MIG Seminar Series - Nicola Armstrong - Common genetic variation indicates separate etiologies for periventricular and deep white matter hyperintensities

Seminar/Forum

MIG Seminar Series - Nicola Armstrong - Common genetic variation indicates separate etiologies for periventricular and deep white matter hyperintensities

Common genetic variation indicates separate etiologies for periventricular and deep white matter hyperintensities

Abstract: White matter hyperintensities (WMHs) can be classified as deep (DWMH) and periventricular (PV) WMH dependent upon their anatomical location in relation to the lateral ventricle and subcortical space. This categorisation is thought to be reflected by etiological and clinical pathophysiological differences between DWMH and PVWMH. WMHs are associated with cognitive functional impairments and are strongly correlated with neurodegenerative and neuropsychiatric disorders including Alzheimer’s and vascular dementia. Heritability studies indicate significant (non-identical) heritability coefficients for DWMH and PVWMH. We recently carried out a GWAS in 24,571 participants from CHARGE, ENIGMA, and UK biobank (UKBB) for these phenotypes. Here I will give an overview of our journey from project conception to submission.

Presenter

  • Associate Professor Nicola Armstrong